Babassu oil extraction is the main income source in nut breakers communities in northeast of Brazil. Among these communities,\nbabassu oil is used for cooking but also medically to treat skin wounds and inflammation, and vulvovaginitis. This study aimed to\nevaluate the anti-inflammatory activity of babassu oil and develop a microemulsion system with babassu oil for topical delivery.\nTopical anti-inflammatory activity was evaluated in mice ear edema using PMA, arachidonic acid, ethyl phenylpropiolate, phenol,\nand capsaicin as phlogistic agents. A microemulsion system was successfully developed using a Span 80/Kolliphor EL ratio of\n6 : 4 as the surfactant system (S), propylene glycol and water (3 : 1) as the aqueous phase (A), and babassu oil as the oil phase (O), and\nanalyzed through conductivity, SAXS, DSC, TEM, and rheological assays. Babassu oil and lauric acid showed anti-inflammatory\nactivity in mice ear edema, through inhibition of eicosanoid pathway and bioactive amines. The developed formulation (39%\nA, 12.2% O, and 48.8% S) was classified as a bicontinuous to o/w transition microemulsion that showed a Newtonian profile.\nThe topical anti-inflammatory activity of microemulsified babassu oil was markedly increased. A new delivery system of babassu\nmicroemulsion droplet clusters was designed to enhance the therapeutic efficacy of vegetable oil.
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